Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis
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چکیده
منابع مشابه
Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis
Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively. Among enzyme-catalyzed epoxide transformations, a reaction that is notably missing, in regard to the synthetic toolbox, is cationic rearrangement that takes place under strong acid. This is a challenging transformation for enzyme catalysis, ...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2017
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.2283